Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM045129-02S1
Application #
3304470
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1991-09-01
Project End
1994-08-31
Budget Start
1992-09-01
Budget End
1993-08-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Belelli, Delia; Harrison, Neil L; Maguire, Jamie et al. (2009) Extrasynaptic GABAA receptors: form, pharmacology, and function. J Neurosci 29:12757-63
Ying, Shui-Wang; Werner, David F; Homanics, Gregg E et al. (2009) Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms. Neuropharmacology 56:438-47
Castaldo, Pasqualina; Stefanoni, Patrizia; Miceli, Francesco et al. (2004) A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists. J Biol Chem 279:25598-604
Kash, Thomas L; Kim, Taeho; Trudell, James R et al. (2004) Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors. Neurosci Lett 371:230-4
Zimmerman, S A; Jones, M V; Harrison, N L (1994) Potentiation of gamma-aminobutyric acidA receptor Cl- current correlates with in vivo anesthetic potency. J Pharmacol Exp Ther 270:987-91
Jones, M V; Harrison, N L (1993) Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons. J Neurophysiol 70:1339-49
Harrison, N L; Kugler, J L; Jones, M V et al. (1993) Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane. Mol Pharmacol 44:628-32