Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM045413-13S1
Application #
6832960
Study Section
Mammalian Genetics Study Section (MGN)
Program Officer
Anderson, Richard A
Project Start
1991-04-01
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
13
Fiscal Year
2004
Total Cost
$52,096
Indirect Cost
Name
Oregon Health and Science University
Department
Genetics
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Johnson, Jennifer R; Erdeniz, Naz; Nguyen, Megan et al. (2010) Conservation of functional asymmetry in the mammalian MutL? ATPase. DNA Repair (Amst) 9:1209-13
Liskay, R Michael; Wheeler, Linda J; Mathews, Christopher K et al. (2007) Involvement of deoxycytidylate deaminase in the response to S(n)1-type methylation DNA damage in budding yeast. Curr Biol 17:R755-7
Tran, Phuoc T; Fey, Julien P; Erdeniz, Naz et al. (2007) A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair. DNA Repair (Amst) 6:1572-83
Erdeniz, Naz; Nguyen, Megan; Deschenes, Suzanne M et al. (2007) Mutations affecting a putative MutLalpha endonuclease motif impact multiple mismatch repair functions. DNA Repair (Amst) 6:1463-70
Deschenes, Suzanne M; Tomer, Guy; Nguyen, Megan et al. (2007) The E705K mutation in hPMS2 exerts recessive, not dominant, effects on mismatch repair. Cancer Lett 249:148-56
Mohd, Azizah B; Palama, Brett; Nelson, Scott E et al. (2006) Truncation of the C-terminus of human MLH1 blocks intracellular stabilization of PMS2 and disrupts DNA mismatch repair. DNA Repair (Amst) 5:347-61
Hegan, Denise Campisi; Narayanan, Latha; Jirik, Frank R et al. (2006) Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis 27:2402-8
Gibson, Shannon L; Narayanan, Latha; Hegan, Denise Campisi et al. (2006) Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance. Cancer Lett 244:195-202
Erdeniz, Naz; Dudley, Sandra; Gealy, Regan et al. (2005) Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication. Mol Cell Biol 25:9221-31
Chen, Peng-Chieh; Dudley, Sandra; Hagen, Wayne et al. (2005) Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Cancer Res 65:8662-70

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