Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM045758-10A1
Application #
6469991
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Program Officer
Okita, Richard T
Project Start
1992-02-01
Project End
2006-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
10
Fiscal Year
2002
Total Cost
$336,813
Indirect Cost
Name
University of Pennsylvania
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Thangavel, Chellappagounder; Shapiro, Bernard H (2008) Inherent sexually dimorphic expression of hepatic CYP2C12 correlated with repressed activation of growth hormone-regulated signal transduction in male rats. Drug Metab Dispos 36:1884-95
Thangavel, Chellappagounder; Dhir, Ravindra N; Volgin, Denys V et al. (2007) Sex-dependent expression of CYP2C11 in spleen, thymus and bone marrow regulated by growth hormone. Biochem Pharmacol 74:1476-84
Dhir, Ravindra N; Thangavel, Chellappagounder; Shapiro, Bernard H (2007) Attenuated expression of episodic growth hormone-induced CYP2C11 in female rats associated with suboptimal activation of the Jak2/Stat5B and other modulating signaling pathways. Drug Metab Dispos 35:2102-10
Thangavel, Chellappagounder; Shapiro, Bernard H (2007) A molecular basis for the sexually dimorphic response to growth hormone. Endocrinology 148:2894-903
Dhir, Ravindra N; Dworakowski, Wojciech; Thangavel, Chellappagounder et al. (2006) Sexually dimorphic regulation of hepatic isoforms of human cytochrome p450 by growth hormone. J Pharmacol Exp Ther 316:87-94
Thangavel, Chellappagounder; Dworakowski, Wojciech; Shapiro, Bernard H (2006) Inducibility of male-specific isoforms of cytochrome p450 by sex-dependent growth hormone profiles in hepatocyte cultures from male but not female rats. Drug Metab Dispos 34:410-9
Verma, Ashish S; Shapiro, Bernard H (2006) Sex-dependent expression of seven housekeeping genes in rat liver. J Gastroenterol Hepatol 21:1004-8
Verma, Ashish S; Dhir, Ravindra N; Shapiro, Bernard H (2005) Inadequacy of the Janus kinase 2/signal transducer and activator of transcription signal transduction pathway to mediate episodic growth hormone-dependent regulation of hepatic CYP2C11. Mol Pharmacol 67:891-901
Thangavel, Chellappagounder; Garcia, Martha C; Shapiro, Bernard H (2004) Intrinsic sex differences determine expression of growth hormone-regulated female cytochrome P450s. Mol Cell Endocrinol 220:31-9
Sharma, Meena R; Periandythevar, Parameswaran; Shapiro, Bernard H (2003) Spurious observation of splenic cyp2b1 expression. Drug Metab Dispos 31:1074-6

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