Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM046422-05
Application #
2183893
Study Section
Molecular Biology Study Section (MBY)
Project Start
1991-09-30
Project End
1997-06-30
Budget Start
1996-05-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Biochemistry
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Viladoms, Julia; Fedor, Martha J (2012) The glmS ribozyme cofactor is a general acid-base catalyst. J Am Chem Soc 134:19043-9
Viladoms, Julia; Scott, Lincoln G; Fedor, Martha J (2011) An active-site guanine participates in glmS ribozyme catalysis in its protonated state. J Am Chem Soc 133:18388-96
Cottrell, Joseph W; Scott, Lincoln G; Fedor, Martha J (2011) The pH dependence of hairpin ribozyme catalysis reflects ionization of an active site adenine. J Biol Chem 286:17658-64
Watson, Peter Y; Fedor, Martha J (2009) Determination of intracellular RNA folding rates using self-cleaving RNAs. Methods Enzymol 468:259-86
Liu, Lu; Cottrell, Joseph W; Scott, Lincoln G et al. (2009) Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme. Nat Chem Biol 5:351-7
Fedor, Martha J (2008) Alternative splicing minireview series: combinatorial control facilitates splicing regulation of gene expression and enhances genome diversity. J Biol Chem 283:1209-10
Cottrell, Joseph W; Kuzmin, Yaroslav I; Fedor, Martha J (2007) Functional analysis of hairpin ribozyme active site architecture. J Biol Chem 282:13498-507
Da Costa, Carla P; Fedor, Martha J; Scott, Lincoln G (2007) 8-Azaguanine reporter of purine ionization states in structured RNAs. J Am Chem Soc 129:3426-32
Kuzmin, Yaroslav I; Da Costa, Carla P; Fedor, Martha J (2004) Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescue. J Mol Biol 340:233-51
Lebruska, Lori L; Kuzmine, Iaroslav I; Fedor, Martha J (2002) Rescue of an abasic hairpin ribozyme by cationic nucleobases: evidence for a novel mechanism of RNA catalysis. Chem Biol 9:465-73

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