Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM047296-04
Application #
2184715
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1993-01-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Microbiology/Immun/Virology
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Bazurto, Jannell V; Heitman, Nicholas J; Downs, Diana M (2015) Aminoimidazole Carboxamide Ribotide Exerts Opposing Effects on Thiamine Synthesis in Salmonella enterica. J Bacteriol 197:2821-30
Ernst, Dustin C; Downs, Diana M (2015) The STM4195 gene product (PanS) transports coenzyme A precursors in Salmonella enterica. J Bacteriol 197:1368-77
Palmer, Lauren D; Paxhia, Michael D; Downs, Diana M (2015) Induction of the Sugar-Phosphate Stress Response Allows Saccharomyces cerevisiae 2-Methyl-4-Amino-5-Hydroxymethylpyrimidine Phosphate Synthase To Function in Salmonella enterica. J Bacteriol 197:3554-62
Bazurto, Jannell V; Downs, Diana M (2014) Amino-4-imidazolecarboxamide ribotide directly inhibits coenzyme A biosynthesis in Salmonella enterica. J Bacteriol 196:772-9
Palmer, Lauren D; Leung, Man Him; Downs, Diana M (2014) The cysteine desulfhydrase CdsH is conditionally required for sulfur mobilization to the thiamine thiazole in Salmonella enterica. J Bacteriol 196:3964-70
Palmer, Lauren D; Downs, Diana M (2013) The thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites. J Biol Chem 288:30693-9
Palmer, Lauren D; Dougherty, Michael J; Downs, Diana M (2012) Analysis of ThiC variants in the context of the metabolic network of Salmonella enterica. J Bacteriol 194:6088-95
Christopherson, Melissa R; Lambrecht, Jennifer A; Downs, Deanna et al. (2012) Suppressor analyses identify threonine as a modulator of ridA mutant phenotypes in Salmonella enterica. PLoS One 7:e43082
Boyd, Jeffrey M; Teoh, Wei Ping; Downs, Diana M (2012) Decreased transport restores growth of a Salmonella enterica apbC mutant on tricarballylate. J Bacteriol 194:576-83
Koenigsknecht, Mark J; Lambrecht, Jennifer A; Fenlon, Luke A et al. (2012) Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica. PLoS One 7:e48207

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