Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM047466-06A2
Application #
2022570
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1991-07-01
Project End
1997-07-31
Budget Start
1996-12-01
Budget End
1997-07-31
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Institute for Cancer Research
Department
Type
DUNS #
872612445
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Khatri, Raju; Shah, Preeti; Guha, Rupa et al. (2015) Aromatase Inhibitor-Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer. Mol Cancer Ther 14:1728-37
Niture, Suryakant K; Khatri, Raju; Jaiswal, Anil K (2014) Regulation of Nrf2-an update. Free Radic Biol Med 66:36-44
Shelton, Phillip; Jaiswal, Anil K (2013) The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene? FASEB J 27:414-23
Niture, Suryakant K; Jaiswal, Anil K (2013) Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance. Free Radic Biol Med 57:119-31
Niture, Suryakant K; Jaiswal, Anil K (2012) Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. J Biol Chem 287:9873-86
Niture, Suryakant K; Jain, Abhinav K; Shelton, Phillip M et al. (2011) Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression. J Biol Chem 286:28821-32
Niture, Suryakant K; Jaiswal, Anil K (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J Biol Chem 286:44542-56
Kaspar, James W; Jaiswal, Anil K (2011) Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression. FASEB J 25:1076-87
Kaspar, James W; Jaiswal, Anil K (2010) Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression. J Biol Chem 285:153-62
Niture, Suryakant K; Kaspar, James W; Shen, Jun et al. (2010) Nrf2 signaling and cell survival. Toxicol Appl Pharmacol 244:37-42

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