Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM047533-05
Application #
2185002
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1992-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Georgia
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Athens
State
GA
Country
United States
Zip Code
30602
Xiang, Yong; Karaveg, Khanita; Moremen, Kelley W (2016) Substrate recognition and catalysis by GH47 ?-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway. Proc Natl Acad Sci U S A 113:E7890-E7899
Zhou, Tao; Frabutt, Dylan A; Moremen, Kelley W et al. (2015) ERManI (Endoplasmic Reticulum Class I ?-Mannosidase) Is Required for HIV-1 Envelope Glycoprotein Degradation via Endoplasmic Reticulum-associated Protein Degradation Pathway. J Biol Chem 290:22184-92
Moremen, Kelley W; Tiemeyer, Michael; Nairn, Alison V (2012) Vertebrate protein glycosylation: diversity, synthesis and function. Nat Rev Mol Cell Biol 13:448-62
Rafiq, Muhammad Arshad; Kuss, Andreas W; Puettmann, Lucia et al. (2011) Mutations in the alpha 1,2-mannosidase gene, MAN1B1, cause autosomal-recessive intellectual disability. Am J Hum Genet 89:176-82
Zhu, Yanping; Suits, Michael D L; Thompson, Andrew J et al. (2010) Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont. Nat Chem Biol 6:125-32
Termine, Daniel J; Moremen, Kelley W; Sifers, Richard N (2009) The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I. J Cell Sci 122:976-84
Zhong, Wei; Kuntz, Douglas A; Ember, Brian et al. (2008) Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J Am Chem Soc 130:8975-83
Akama, Tomoya O; Nakagawa, Hiroaki; Wong, Nyet Kui et al. (2006) Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice. Proc Natl Acad Sci U S A 103:8983-8
Park, Chaeho; Meng, Lu; Stanton, Leslie H et al. (2005) Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism. J Biol Chem 280:37204-16
Moremen, K W; Trimble, R B; Herscovics, A (1994) Glycosidases of the asparagine-linked oligosaccharide processing pathway. Glycobiology 4:113-25

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