Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM048339-05
Application #
2022635
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1992-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Schepens Eye Research Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02114
Kazlauskas, Andrius (2005) The priming/completion paradigm to explain growth factor-dependent cell cycle progression. Growth Factors 23:203-10
Plattner, Rina; Koleske, Anthony J; Kazlauskas, Andrius et al. (2004) Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Mol Cell Biol 24:2573-83
Balciunaite, Egle; Kazlauskas, Andrius (2002) The timing and extent of activation of diacylglycerol-responsive protein kinase-cs determines their ability to inhibit or promote platelet-derived growth factor-dependent DNA synthesis. Exp Cell Res 281:167-74
Balciunaite, E; Kazlauskas, A (2001) Early phosphoinositide 3-kinase activity is required for late activation of protein kinase Cepsilon in platelet-derived-growth-factor-stimulated cells: evidence for signalling across a large temporal gap. Biochem J 358:281-5
Balciunaite, E; Jones, S; Toker, A et al. (2000) PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition. Curr Biol 10:261-7
Schlesinger, T K; Demali, K A; Johnson, G L et al. (1999) Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. Biochem J 344 Pt 2:519-26
Jones, S M; Klinghoffer, R; Prestwich, G D et al. (1999) PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr Biol 9:512-21
DeMali, K A; Balciunaite, E; Kazlauskas, A (1999) Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. J Biol Chem 274:19551-8
DeMali, K A; Kazlauskas, A (1998) Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. Mol Cell Biol 18:2014-22
Rameh, L E; Rhee, S G; Spokes, K et al. (1998) Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. J Biol Chem 273:23750-7

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