Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM048631-06
Application #
2843174
Study Section
Project Start
1998-07-01
Project End
2001-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Wang, Weirong; Cajigas, Ivan J; Peltz, Stuart W et al. (2006) Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay. Mol Cell Biol 26:3390-400
Le Roy, Florence; Salehzada, Tamim; Bisbal, Catherine et al. (2005) A newly discovered function for RNase L in regulating translation termination. Nat Struct Mol Biol 12:505-12
Gonzalez, C I; Bhattacharya, A; Wang, W et al. (2001) Nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Gene 274:15-25
Wang, W; Czaplinski, K; Rao, Y et al. (2001) The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts. EMBO J 20:880-90
Gonzalez, C I; Wang, W; Peltz, S W (2001) Nonsense-mediated mRNA decay in Saccharomyces cerevisiae: a quality control mechanism that degrades transcripts harboring premature termination codons. Cold Spring Harb Symp Quant Biol 66:321-8
Wilusz, C J; Wang, W; Peltz, S W (2001) Curbing the nonsense: the activation and regulation of mRNA surveillance. Genes Dev 15:2781-5
Gonzalez, C I; Ruiz-Echevarria, M J; Vasudevan, S et al. (2000) The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay. Mol Cell 5:489-99
Ruiz-Echevarria, M J; Peltz, S W (2000) The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames. Cell 101:741-51
Bhattacharya, A; Czaplinski, K; Trifillis, P et al. (2000) Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA 6:1226-35
Czaplinski, K; Majlesi, N; Banerjee, T et al. (2000) Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency. RNA 6:730-43

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