Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049217-03
Application #
2186770
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1994-01-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Steblyanko, Maria; Anikeeva, Nadia; Campbell, Kerry S et al. (2015) Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner. J Biol Chem 290:11833-42
Majeed, Sophia R; Vasudevan, Lavanya; Chen, Chih-Ying et al. (2014) Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. Nat Commun 5:3891
Chen, Xiaole L; Chinchilla, Pilar; Fombonne, Joanna et al. (2014) Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog. Mol Cell Biol 34:3855-66
Luo, Yi; Zhan, Yi; Keen, James H (2013) Arf6 regulation of Gyrating-clathrin. Traffic 14:97-106
Parachoniak, Christine Anna; Luo, Yi; Abella, Jasmine Vanessa et al. (2011) GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration. Dev Cell 20:751-63
Varma, Dileep; Dawn, Amrita; Ghosh-Roy, Anindya et al. (2010) Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes. Proc Natl Acad Sci U S A 107:3493-8
Zhao, Yanqiu; Keen, James H (2008) Gyrating clathrin: highly dynamic clathrin structures involved in rapid receptor recycling. Traffic 9:2253-64
Zhao, Yanqiu; Gaidarov, Ibragim; Keen, James H (2007) Phosphoinositide 3-kinase C2alpha links clathrin to microtubule-dependent movement. J Biol Chem 282:1249-56
Gaidarov, Ibragim; Zhao, Yanqiu; Keen, James H (2005) Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function. J Biol Chem 280:40766-72
Gaidarov, I; Smith, M E; Domin, J et al. (2001) The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol Cell 7:443-9

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