Abstract

The long-term goal of our work is to understand vertebrate development at the molecular level. In previous grant periods, we have characterized the activities of BMP antagonists. In the next five years, we will examine the biological roles and mechanisms of antagonists of TGF-beta 3 family members further, with a particular emphasis on their roles in organogenesis. These experiments will rely on gain of function analysis in Xenopus and loss of function analysis in the mouse. The experiments will be complemented by biochemical analysis of the mechanisms by which antagonists block BMP function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049346-11
Application #
6636082
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Greenberg, Judith H
Project Start
1993-05-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
11
Fiscal Year
2003
Total Cost
$275,984
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Young, John J; Kjolby, Rachel A S; Wu, Gloria et al. (2017) Noggin is required for first pharyngeal arch differentiation in the frog Xenopus tropicalis. Dev Biol 426:245-254
Stafford, David A; Dichmann, Darwin S; Chang, Jessica K et al. (2017) Deletion of the sclerotome-enriched lncRNA PEAT augments ribosomal protein expression. Proc Natl Acad Sci U S A 114:101-106
Ray, Ayan; Singh, Pratik Narendra Pratap; Sohaskey, Michael L et al. (2015) Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation. Development 142:1169-79
Stafford, David A; Monica, Stefanie D; Harland, Richard M (2014) Follistatin interacts with Noggin in the development of the axial skeleton. Mech Dev 131:78-85
Canalis, Ernesto; Brunet, Lisa J; Parker, Kristen et al. (2012) Conditional inactivation of noggin in the postnatal skeleton causes osteopenia. Endocrinology 153:1616-26
Stafford, David A; Brunet, Lisa J; Khokha, Mustafa K et al. (2011) Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development 138:1005-14
Harland, Richard M; Grainger, Robert M (2011) Xenopus research: metamorphosed by genetics and genomics. Trends Genet 27:507-15
Wills, Andrea E; Choi, Vivian M; Bennett, Margaux J et al. (2010) BMP antagonists and FGF signaling contribute to different domains of the neural plate in Xenopus. Dev Biol 337:335-50
Sohaskey, Michael L; Jiang, Yebin; Zhao, Jenny J et al. (2010) Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. J Cell Biol 189:511-25
Sohaskey, Michael L; Yu, Jane; Diaz, Michael A et al. (2008) JAWS coordinates chondrogenesis and synovial joint positioning. Development 135:2215-20

Showing the most recent 10 out of 21 publications