Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049649-02
Application #
2187175
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1995-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Georgetown University
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Madison, K Elizabeth; Jones-Foster, Erica N; Vogt, Andrea et al. (2014) Stringent response processes suppress DNA damage sensitivity caused by deficiency in full-length translation initiation factor 2 or PriA helicase. Mol Microbiol 92:28-46
Madison, K Elizabeth; Abdelmeguid, Mona R; Jones-Foster, Erica N et al. (2012) A new role for translation initiation factor 2 in maintaining genome integrity. PLoS Genet 8:e1002648
North, Stella H; Kirtland, Sandy E; Nakai, Hiroshi (2007) Translation factor IF2 at the interface of transposition and replication by the PriA-PriC pathway. Mol Microbiol 66:1566-78
Rothery, Richard A; Seime, Andrea M; Spiers, A-M Caroline et al. (2005) Defining the Q-site of Escherichia coli fumarate reductase by site-directed mutagenesis, fluorescence quench titrations and EPR spectroscopy. FEBS J 272:313-26
North, Stella H; Nakai, Hiroshi (2005) Host factors that promote transpososome disassembly and the PriA-PriC pathway for restart primosome assembly. Mol Microbiol 56:1601-16
Chen, Hua-Wei; North, Stella H; Nakai, Hiroshi (2004) Properties of the PriA helicase domain and its role in binding PriA to specific DNA structures. J Biol Chem 279:38503-12
Jones, J M; Nakai, H (2001) Escherichia coli PriA helicase: fork binding orients the helicase to unwind the lagging strand side of arrested replication forks. J Mol Biol 312:935-47
Nakai, H; Doseeva, V; Jones, J M (2001) Handoff from recombinase to replisome: insights from transposition. Proc Natl Acad Sci U S A 98:8247-54
Jones, J M; Nakai, H (2000) PriA and phage T4 gp59: factors that promote DNA replication on forked DNA substrates microreview. Mol Microbiol 36:519-27
Jones, J M; Nakai, H (1999) Duplex opening by primosome protein PriA for replisome assembly on a recombination intermediate. J Mol Biol 289:503-16

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