Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM049928-04
Application #
2187495
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1993-09-01
Project End
2000-07-31
Budget Start
1996-08-06
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Chemistry
Type
Other Domestic Higher Education
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Danhart, Eric M; Bakhtina, Marina; Cantara, William A et al. (2017) Conformational and chemical selection by a trans-acting editing domain. Proc Natl Acad Sci U S A 114:E6774-E6783
Liu, Ziwei; Vargas-Rodriguez, Oscar; Goto, Yuki et al. (2015) Homologous trans-editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation. Proc Natl Acad Sci U S A 112:6027-32
Novoa, Eva Maria; Vargas-Rodriguez, Oscar; Lange, Stefanie et al. (2015) Ancestral AlaX editing enzymes for control of genetic code fidelity are not tRNA-specific. J Biol Chem 290:10495-503
Bartholow, Thomas G; Sanford, Brianne L; Cao, Bach et al. (2014) Strictly conserved lysine of prolyl-tRNA Synthetase editing domain facilitates binding and positioning of misacylated tRNA(Pro.). Biochemistry 53:1059-68
Alemán, Elvin A; de Silva, Chamaree; Patrick, Eric M et al. (2014) Single-Molecule Fluorescence Using Nucleotide Analogs: A Proof-of-Principle. J Phys Chem Lett 5:777-781
Dewan, Varun; Reader, John; Forsyth, Karin-Musier (2014) Role of aminoacyl-tRNA synthetases in infectious diseases and targets for therapeutic development. Top Curr Chem 344:293-329
Das, Mom; Vargas-Rodriguez, Oscar; Goto, Yuki et al. (2014) Distinct tRNA recognition strategies used by a homologous family of editing domains prevent mistranslation. Nucleic Acids Res 42:3943-53
Kumar, Sandeep; Das, Mom; Hadad, Christopher M et al. (2013) Aminoacyl-tRNA substrate and enzyme backbone atoms contribute to translational quality control by YbaK. J Phys Chem B 117:4521-7
Johnson, James M; Sanford, Brianne L; Strom, Alexander M et al. (2013) Multiple pathways promote dynamical coupling between catalytic domains in Escherichia coli prolyl-tRNA synthetase. Biochemistry 52:4399-412
Vargas-Rodriguez, Oscar; Musier-Forsyth, Karin (2013) Exclusive use of trans-editing domains prevents proline mistranslation. J Biol Chem 288:14391-9

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