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Lee, Jyh-Yeuan; Urbatsch, Ina L; Senior, Alan E et al. (2008) Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy. J Biol Chem 283:5769-79
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Tombline, Gregory; Donnelly, David J; Holt, Jason J et al. (2006) Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the ""R"" site to the ATP hydrolysis transition state. Biochemistry 45:8034-47
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Tombline, Gregory; Urbatsch, Ina L; Virk, Navneet et al. (2006) Expression, purification, and characterization of cysteine-free mouse P-glycoprotein. Arch Biochem Biophys 445:124-8
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Tombline, Gregory; Senior, Alan E (2005) The occluded nucleotide conformation of p-glycoprotein. J Bioenerg Biomembr 37:497-500
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Delannoy, Sabine; Urbatsch, Ina L; Tombline, Gregory et al. (2005) Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy. Biochemistry 44:14010-9
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Tombline, Gregory; Muharemagic, Alma; White, Lori Bartholomew et al. (2005) Involvement of the ""occluded nucleotide conformation"" of P-glycoprotein in the catalytic pathway. Biochemistry 44:12879-86
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Tombline, Gregory; Bartholomew, Lori A; Urbatsch, Ina L et al. (2004) Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly. J Biol Chem 279:31212-20
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Tombline, Gregory; Bartholomew, Lori A; Tyndall, Grace A et al. (2004) Properties of P-glycoprotein with mutations in the ""catalytic carboxylate"" glutamate residues. J Biol Chem 279:46518-26
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Tombline, Gregory; Bartholomew, Lori; Gimi, Khursheed et al. (2004) Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis. J Biol Chem 279:5363-73
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Urbatsch, Ina L; Tyndall, Grace A; Tombline, Gregory et al. (2003) P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state. J Biol Chem 278:23171-9
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