Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050313-03
Application #
2188059
Study Section
Molecular Biology Study Section (MBY)
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Biochemistry
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Zhao, Chen; Liu, Fei; Pyle, Anna Marie (2018) An ultraprocessive, accurate reverse transcriptase encoded by a metazoan group II intron. RNA 24:183-195
Fedorova, Olga; Jagdmann Jr, G Erik; Adams, Rebecca L et al. (2018) Small molecules that target group II introns are potent antifungal agents. Nat Chem Biol 14:1073-1078
Liu, Fei; Somarowthu, Srinivas; Pyle, Anna Marie (2017) Visualizing the secondary and tertiary architectural domains of lncRNA RepA. Nat Chem Biol 13:282-289
Dickey, Thayne H; Pyle, Anna M (2017) The SMAD3 transcription factor binds complex RNA structures with high affinity. Nucleic Acids Res 45:11980-11988
Zhao, Chen; Pyle, Anna Marie (2017) Structural Insights into the Mechanism of Group II Intron Splicing. Trends Biochem Sci 42:470-482
Zhao, Chen; Pyle, Anna Marie (2017) The group II intron maturase: a reverse transcriptase and splicing factor go hand in hand. Curr Opin Struct Biol 47:30-39
Zhao, Chen; Pyle, Anna Marie (2016) Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nat Struct Mol Biol 23:558-65
Somarowthu, Srinivas (2016) Progress and Current Challenges in Modeling Large RNAs. J Mol Biol 428:736-747
Pyle, Anna Marie (2016) Group II Intron Self-Splicing. Annu Rev Biophys 45:183-205
Marcia, Marco (2016) Using Molecular Replacement Phasing to Study the Structure and Function of RNA. Methods Mol Biol 1320:233-57

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