Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050388-03
Application #
2188197
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Pharmacology
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Subramanian, Thangaiah; Ren, Hongmei; Subramanian, Karunai Leela et al. (2014) Design and synthesis of non-hydrolyzable homoisoprenoid ?-monofluorophosphonate inhibitors of PPAPDC family integral membrane lipid phosphatases. Bioorg Med Chem Lett 24:4414-4417
Wu, Tao; Kooi, Craig Vander; Shah, Pritom et al. (2014) Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration. FASEB J 28:861-70
Jonnalagadda, Deepa; Sunkara, Manjula; Morris, Andrew J et al. (2014) Granule-mediated release of sphingosine-1-phosphate by activated platelets. Biochim Biophys Acta 1841:1581-9
Panchatcharam, Manikandan; Salous, Abdel K; Brandon, Jason et al. (2014) Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability. Arterioscler Thromb Vasc Biol 34:837-45
Deevska, Gergana; Sunkara, Manjula; Karakashian, Claudia et al. (2014) Effect of procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3. J Lipid Res 55:2041-52
Smyth, Susan S; Mueller, Paul; Yang, Fanmuyi et al. (2014) Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis. Arterioscler Thromb Vasc Biol 34:479-86
Onono, Fredrick; Subramanian, Thangaiah; Sunkara, Manjula et al. (2013) Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. J Biol Chem 288:27444-55
Panchatcharam, Manikandan; Miriyala, Sumitra; Salous, Abdelghaffar et al. (2013) Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia. Arterioscler Thromb Vasc Biol 33:52-9
Subramanian, Thangaiah; Subramanian, Karunai Leela; Sunkara, Manjula et al. (2013) Syntheses of deuterium labeled prenyldiphosphate and prenylcysteine analogues for in vivo mass spectrometric quantification. J Labelled Comp Radiopharm 56:370-5
Karapetyan, Anush V; Klyachkin, Yuri M; Selim, Samy et al. (2013) Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. Stem Cells Dev 22:1645-56

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