Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050412-03
Application #
2188247
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1994-01-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Sivakumar, Sushama; Janczyk, Pawe? ?; Qu, Qianhui et al. (2016) The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores. Elife 5:
Sivakumar, Sushama; Daum, John R; Gorbsky, Gary J (2014) Live-cell fluorescence imaging for phenotypic analysis of mitosis. Methods Mol Biol 1170:549-62
Sivakumar, Sushama; Daum, John R; Tipton, Aaron R et al. (2014) The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit. Mol Biol Cell 25:594-605
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Wang, Fangwei; Ulyanova, Natalia P; Daum, John R et al. (2012) Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol 199:251-68
Daum, John R; Potapova, Tamara A; Sivakumar, Sushama et al. (2011) Cohesion fatigue induces chromatid separation in cells delayed at metaphase. Curr Biol 21:1018-24
Potapova, Tamara A; Sivakumar, Sushama; Flynn, Jennifer N et al. (2011) Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited. Mol Biol Cell 22:1191-206
Hu, Lulin; Potapova, Tamara A; Li, Shibo et al. (2010) Expression of HPV16 E5 produces enlarged nuclei and polyploidy through endoreplication. Virology 405:342-51
Gorbsky, Gary J (2010) Duct tape for broken chromosomes. Cell 140:178-80
Wang, Fangwei; Dai, Jun; Daum, John R et al. (2010) Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science 330:231-5

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