Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050877-03
Application #
2189030
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1994-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Utah
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Hoffman, Laura; Jensen, Christopher C; Yoshigi, Masaaki et al. (2017) Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1. Mol Biol Cell 28:2661-2675
Rosner, Sonia R; Pascoe, Christopher D; Blankman, Elizabeth et al. (2017) The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. PLoS One 12:e0171728
Piccolo, Stephen R; Hoffman, Laura M; Conner, Thomas et al. (2016) Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. Mol Syst Biol 12:860
Stachowiak, Matthew R; Smith, Mark A; Blankman, Elizabeth et al. (2014) A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton. Proc Natl Acad Sci U S A 111:17528-33
Chaturvedi, Aashi; Hoffman, Laura M; Jensen, Christopher C et al. (2014) Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. Mol Biol Cell 25:2695-709
Sankar, Savita; Theisen, Emily R; Bearss, Jared et al. (2014) Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clin Cancer Res 20:4584-97
Smith, M A; Hoffman, L M; Beckerle, M C (2014) LIM proteins in actin cytoskeleton mechanoresponse. Trends Cell Biol 24:575-83
Chapin, L M; Edgar, L T; Blankman, E et al. (2014) Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cell Mol Bioeng 7:73-85
Smith, Mark A; Blankman, Elizabeth; Deakin, Nicholas O et al. (2013) LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One 8:e69378
Clark, Kathleen A; Kadrmas, Julie L (2013) Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking. Cytoskeleton (Hoboken) 70:304-16

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