Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM051265-03
Application #
2189662
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
McAlister-Henn, Lee (2012) Ligand binding and structural changes associated with allostery in yeast NAD(+)-specific isocitrate dehydrogenase. Arch Biochem Biophys 519:112-7
Lin, An-Ping; Demeler, Borries; Minard, Karyl I et al. (2011) Construction and analyses of tetrameric forms of yeast NAD+-specific isocitrate dehydrogenase. Biochemistry 50:230-9
Lin, An-Ping; McAlister-Henn, Lee (2011) Basis for half-site ligand binding in yeast NAD(+)-specific isocitrate dehydrogenase. Biochemistry 50:8241-50
Lin, An-Ping; Anderson, Sondra L; Minard, Karyl I et al. (2011) Effects of excess succinate and retrograde control of metabolite accumulation in yeast tricarboxylic cycle mutants. J Biol Chem 286:33737-46
Minard, Karyl I; McAlister-Henn, Lee (2010) Pnc1p supports increases in cellular NAD(H) levels in response to internal or external oxidative stress. Biochemistry 49:6299-301
Lu, Qian; McAlister-Henn, Lee (2010) Peroxisomal localization and function of NADP+ -specific isocitrate dehydrogenases in yeast. Arch Biochem Biophys 493:125-34
Minard, Karyl I; McAlister-Henn, L (2009) Redox responses in yeast to acetate as the carbon source. Arch Biochem Biophys 483:136-43
Garcia, Joshua A; Minard, Karyl I; Lin, An-Ping et al. (2009) Disulfide bond formation in yeast NAD+-specific isocitrate dehydrogenase. Biochemistry 48:8869-78
Lin, An-Ping; Hakala, Kevin W; Weintraub, Susan T et al. (2008) Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase. Arch Biochem Biophys 474:205-12
Hu, Gang; Taylor, Alexander B; McAlister-Henn, Lee et al. (2007) Crystal structure of the yeast nicotinamidase Pnc1p. Arch Biochem Biophys 461:66-75

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