Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM051491-03
Application #
2190059
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Haque, Mohammad Mahfuzul; Tejero, Jesús; Bayachou, Mekki et al. (2018) A cross-domain charge interaction governs the activity of NO synthase. J Biol Chem 293:4545-4554
Ghosh, Arnab; Garee, Greer; Sweeny, Elizabeth A et al. (2018) Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells. Proc Natl Acad Sci U S A 115:E1117-E1126
Dai, Yue; Haque, Mohammad Mahfuzul; Stuehr, Dennis J (2017) Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis. J Biol Chem 292:6753-6764
AlTawallbeh, Ghaith; Haque, Mohammad M; Streletzky, Kiril A et al. (2017) Endothelial nitric oxide synthase oxygenase on lipid nanodiscs: A nano-assembly reflecting native-like function of eNOS. Biochem Biophys Res Commun 493:1438-1442
Haque, Mohammad Mahfuzul; Ray, Sougata Sinha; Stuehr, Dennis J (2016) Phosphorylation Controls Endothelial Nitric-oxide Synthase by Regulating Its Conformational Dynamics. J Biol Chem 291:23047-23057
Ghosh, Arnab; Koziol-White, Cynthia J; Asosingh, Kewal et al. (2016) Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma. Proc Natl Acad Sci U S A 113:E2355-62
Ramasamy, Somasundaram; Haque, Mohammad Mahfuzul; Gangoda, Mahinda et al. (2016) Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery. FEBS J 283:4491-4501
Rwere, Freeborn; Xia, Chuanwu; Im, Sangchoul et al. (2016) Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. J Biol Chem 291:14639-61
Sarkar, Anindya; Dai, Yue; Haque, Mohammad Mahfuzul et al. (2015) Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation. J Biol Chem 290:21615-28
Hannibal, Luciana; Page, Richard C; Haque, Mohammad Mahfuzul et al. (2015) Dissecting structural and electronic effects in inducible nitric oxide synthase. Biochem J 467:153-65

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