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Queener, S F; Cody, V; Pace, J et al. (2013) Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii. Antimicrob Agents Chemother 57:4990-8
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Cody, Vivian; Pace, Jim; Queener, Sherry F et al. (2013) Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants. Antimicrob Agents Chemother 57:2669-77
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Cody, Vivian; Pace, Jim; Stewart, Elizabeth (2012) Structural analysis of Pneumocystis carinii dihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine. Acta Crystallogr Sect F Struct Biol Cryst Commun 68:418-23
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Cody, Vivian; Pace, Jim; Piraino, Jennifer et al. (2011) Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. J Struct Biol 176:52-9
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Cody, Vivian; Pace, Jim (2011) Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-(?-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives. Acta Crystallogr D Biol Crystallogr 67:1-7
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Cody, Vivian; Piraino, Jennifer; Pace, Jim et al. (2010) Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase. Acta Crystallogr D Biol Crystallogr 66:1271-7
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Cody, Vivian; Pace, Jim; Lin, Lu et al. (2009) The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex. Acta Crystallogr Sect F Struct Biol Cryst Commun 65:762-6
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Cody, Vivian; Pace, Jim; Makin, Jennifer et al. (2009) Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes. Biochemistry 48:1702-11
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Gangjee, Aleem; Li, Wei; Lin, Lu et al. (2009) Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem 17:7324-36
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Gangjee, Aleem; Li, Wei; Kisliuk, Roy L et al. (2009) Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. J Med Chem 52:4892-902
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Showing the most recent 10 out of 14 publications
