Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052170-10
Application #
6687780
Study Section
Medical Biochemistry Study Section (MEDB)
Program Officer
Ikeda, Richard A
Project Start
1994-12-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
10
Fiscal Year
2004
Total Cost
$277,200
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Lu, Jian-Ming; Rogge, Corina E; Wu, Gang et al. (2011) Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping. J Inorg Biochem 105:356-65
Wu, Gang; Lu, Jian-Ming; van der Donk, Wilfred A et al. (2011) Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects. J Inorg Biochem 105:382-90
Tsai, Ah-lim; Wu, Gang; Rogge, Corina E et al. (2011) Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2. J Inorg Biochem 105:366-74
Tsai, Ah-Lim; Kulmacz, Richard J (2010) Prostaglandin H synthase: resolved and unresolved mechanistic issues. Arch Biochem Biophys 493:103-24
Wu, Gang; Tsai, Ah-Lim; Kulmacz, Richard J (2009) Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2. Biochemistry 48:11902-11
Rogge, Corina E; Liu, Wen; Kulmacz, Richard J et al. (2009) Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1. J Inorg Biochem 103:912-22
Rand Doyen, J; Yucer, Nur; Lichtenberger, Lenard M et al. (2008) Phospholipid actions on PGHS-1 and -2 cyclooxygenase kinetics. Prostaglandins Other Lipid Mediat 85:134-43
Wu, Gang; Rogge, Corina E; Wang, Jinn-Shyan et al. (2007) Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation. Biochemistry 46:534-42
Liu, Wen; Cao, Dazhe; Oh, Sungwhan F et al. (2006) Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J 20:1097-108
Liu, W; Wang, L-H; Fabian, P et al. (2006) Arabidopsis thaliana fatty acid alpha-dioxygenase-1: evaluation of substrates, inhibitors and amino-terminal function. Plant Physiol Biochem 44:284-93

Showing the most recent 10 out of 37 publications