Special mechanisms of mutation are induced in bacteria and yeasts under growth-limiting stress causing genetic instability, and occasionally, adaptive mutations that may speed evolution. These stress-induced mutation mechanisms may provide superior models for genetic changes that promote aging, genetic instability underlying cancer formation, progression and acquisition of chemotherapy resistance, resistance of pathogens to host defenses and antibiotics, and possibly much of evolution generally. This proposal focuses on understanding the molecular mechanisms of stress-induced genetic instability in an E. coli model. Because the mechanism studied has common components with several other (less understood) mechanisms of stress-induced mutation, the results should provide an important general model.
| Fitzgerald, Devon M; Hastings, P J; Rosenberg, Susan M (2017) Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance. Annu Rev Cancer Biol 1:119-140 |
| Dohrmann, Paul R; Correa, Raul; Frisch, Ryan L et al. (2016) The DNA polymerase III holoenzyme contains ? and is not a trimeric polymerase. Nucleic Acids Res 44:1285-97 |
| Nehring, Ralf B; Gu, Franklin; Lin, Hsin-Yu et al. (2016) An ultra-dense library resource for rapid deconvolution of mutations that cause phenotypes in Escherichia coli. Nucleic Acids Res 44:e41 |
| Barreto, Brittany; Rogers, Elizabeth; Xia, Jun et al. (2016) The Small RNA GcvB Promotes Mutagenic Break Repair by Opposing the Membrane Stress Response. J Bacteriol 198:3296-3308 |
| Moore, Jessica M; Magnan, David; Mojica, Ana K et al. (2015) Roles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in Starving Escherichia coli. Genetics 201:1349-62 |
| Gibson, Janet L; Lombardo, Mary-Jane; Aponyi, Ildiko et al. (2015) Atypical Role for PhoU in Mutagenic Break Repair under Stress in Escherichia coli. PLoS One 10:e0123315 |
| Bos, Julia; Zhang, Qiucen; Vyawahare, Saurabh et al. (2015) Emergence of antibiotic resistance from multinucleated bacterial filaments. Proc Natl Acad Sci U S A 112:178-83 |
| Rosenberg, Susan M; Queitsch, Christine (2014) Medicine. Combating evolution to fight disease. Science 343:1088-9 |
| Wimberly, Hallie; Shee, Chandan; Thornton, P C et al. (2013) R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli. Nat Commun 4:2115 |
| Walker, Sara Imari; Callahan, Benjamin J; Arya, Gaurav et al. (2013) Evolutionary dynamics and information hierarchies in biological systems. Ann N Y Acad Sci 1305:1-17 |
Showing the most recent 10 out of 60 publications
