Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM053228-02S1
Application #
2441189
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Microbiology/Immun/Virology
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Smith, Aaron T; Marvin, Katherine A; Freeman, Katherine M et al. (2012) Identification of Cys94 as the distal ligand to the Fe(III) heme in the transcriptional regulator RcoM-2 from Burkholderia xenovorans. J Biol Inorg Chem 17:1071-82
Kerby, Robert L; Roberts, Gary P (2012) Burkholderia xenovorans RcoM(Bx)-1, a transcriptional regulator system for sensing low and persistent levels of carbon monoxide. J Bacteriol 194:5803-16
Kerby, Robert L; Roberts, Gary P (2011) Sustaining N2-dependent growth in the presence of CO. J Bacteriol 193:774-7
Serate, Jose; Roberts, Gary P; Berg, Otto et al. (2011) Ligand responses of Vfr, the virulence factor regulator from Pseudomonas aeruginosa. J Bacteriol 193:4859-68
Leduc, Jason L; Roberts, Gary P (2009) Cyclic di-GMP allosterically inhibits the CRP-like protein (Clp) of Xanthomonas axonopodis pv. citri. J Bacteriol 191:7121-2
Tobelmann, Matthew D; Kerby, Robert L; Murphy, Regina M (2008) A strategy for generating polyglutamine 'length libraries'in model host proteins. Protein Eng Des Sel 21:161-4
Marvin, Katherine A; Kerby, Robert L; Youn, Hwan et al. (2008) The transcription regulator RcoM-2 from Burkholderia xenovorans is a cysteine-ligated hemoprotein that undergoes a redox-mediated ligand switch. Biochemistry 47:9016-28
Kerby, Robert L; Youn, Hwan; Roberts, Gary P (2008) RcoM: a new single-component transcriptional regulator of CO metabolism in bacteria. J Bacteriol 190:3336-43
Youn, Hwan; Koh, Junseock; Roberts, Gary P (2008) Two-state allosteric modeling suggests protein equilibrium as an integral component for cyclic AMP (cAMP) specificity in the cAMP receptor protein of Escherichia coli. J Bacteriol 190:4532-40
Ibrahim, Mohammed; Kuchinskas, Michael; Youn, Hwan et al. (2007) Mechanism of the CO-sensing heme protein CooA: new insights from the truncated heme domain and UVRR spectroscopy. J Inorg Biochem 101:1776-85

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