Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053960-01
Application #
2193357
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Deweese, Joseph E; Osheroff, Neil (2010) The use of divalent metal ions by type II topoisomerases. Metallomics 2:450-9
Deweese, Joseph E; Guengerich, F Peter; Burgin, Alex B et al. (2009) Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry 48:8940-7
Deweese, Joseph E; Burch, Amber M; Burgin, Alex B et al. (2009) Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. Biochemistry 48:1862-9
Deweese, Joseph E; Osheroff, Neil (2009) Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons. Biochemistry 48:1439-41
Deweese, Joseph E; Osheroff, Michael A; Osheroff, Neil (2008) DNA Topology and Topoisomerases: Teaching a ""Knotty"" Subject. Biochem Mol Biol Educ 37:2-10
Wilstermann, Amy M; Bender, Ryan P; Godfrey, Murrell et al. (2007) Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. Biochemistry 46:8217-25
McClendon, A Kathleen; Osheroff, Neil (2007) DNA topoisomerase II, genotoxicity, and cancer. Mutat Res 623:83-97
Felix, Carolyn A; Kolaris, Christos P; Osheroff, Neil (2006) Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst) 5:1093-108