Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM054397-35
Application #
2634808
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1976-01-01
Project End
1999-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
35
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Harvard University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Hernandez, Alfredo J; Richardson, Charles C (2018) Gp2.5, the multifunctional bacteriophage T7 single-stranded DNA binding protein. Semin Cell Dev Biol :
Hernandez, Alfredo J; Richardson, Charles C (2017) Kinetics of Lagging-strand DNA Synthesis In Vitro by the Bacteriophage T7 Replication Proteins. J Vis Exp :
Hernandez, Alfredo J; Lee, Seung-Joo; Richardson, Charles C (2016) Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome. Proc Natl Acad Sci U S A 113:5916-21
Tran, Ngoc Q; Tabor, Stanley; Richardson, Charles C (2014) Genetic requirements for sensitivity of bacteriophage t7 to dideoxythymidine. J Bacteriol 196:2842-50
Mitsunobu, Hitoshi; Zhu, Bin; Lee, Seung-Joo et al. (2014) Flap endonuclease activity of gene 6 exonuclease of bacteriophage T7. J Biol Chem 289:5860-75
Akabayov, Barak; Akabayov, Sabine R; Lee, Seung-Joo et al. (2013) Impact of macromolecular crowding on DNA replication. Nat Commun 4:1615
Zhu, Bin; Tabor, Stanley; Raytcheva, Desislava A et al. (2013) The RNA polymerase of marine cyanophage Syn5. J Biol Chem 288:3545-52
Tran, Ngoc Q; Tabor, Stanley; Amarasiriwardena, Chitra J et al. (2012) Characterization of a nucleotide kinase encoded by bacteriophage T7. J Biol Chem 287:29468-78
Tran, Ngoc Q; Lee, Seung-Joo; Akabayov, Barak et al. (2012) Thioredoxin, the processivity factor, sequesters an exposed cysteine in the thumb domain of bacteriophage T7 DNA polymerase. J Biol Chem 287:39732-41
Zhu, Bin; Lee, Seung-Joo; Tan, Min et al. (2012) Gene 5.5 protein of bacteriophage T7 in complex with Escherichia coli nucleoid protein H-NS and transfer RNA masks transfer RNA priming in T7 DNA replication. Proc Natl Acad Sci U S A 109:8050-5

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