Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM054642-01
Application #
2193987
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1996-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of South Alabama
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
Mayor, June A; Sun, Jiakang; Kotaria, Rusudan et al. (2010) Probing the effect of transport inhibitors on the conformation of the mitochondrial citrate transport protein via a site-directed spin labeling approach. J Bioenerg Biomembr 42:99-109
Sun, Jiakang; Aluvila, Sreevidya; Kotaria, Rusudan et al. (2010) Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure/Function Analysis. Mol Cell Pharmacol 2:101-110
Aluvila, Sreevidya; Sun, Jiakang; Harrison, David H T et al. (2010) Inhibitors of the mitochondrial citrate transport protein: validation of the role of substrate binding residues and discovery of the first purely competitive inhibitor. Mol Pharmacol 77:26-34
Aluvila, Sreevidya; Kotaria, Rusudan; Sun, Jiakang et al. (2010) The yeast mitochondrial citrate transport protein: molecular determinants of its substrate specificity. J Biol Chem 285:27314-26
Remani, Sreevidya; Sun, Jiakang; Kotaria, Rusudan et al. (2008) The yeast mitochondrial citrate transport protein: identification of the Lysine residues responsible for inhibition mediated by Pyridoxal 5'-phosphate. J Bioenerg Biomembr 40:577-85
Ma, Chunlong; Remani, Sreevidya; Sun, Jiakang et al. (2007) Identification of the substrate binding sites within the yeast mitochondrial citrate transport protein. J Biol Chem 282:17210-20
Ma, Chunlong; Remani, Sreevidya; Kotaria, Rusudan et al. (2006) The mitochondrial citrate transport protein: evidence for a steric interaction between glutamine 182 and leucine 120 and its relationship to the substrate translocation pathway and identification of other mechanistically essential residues. Biochim Biophys Acta 1757:1271-6
Ma, Chunlong; Kotaria, Rusudan; Mayor, June A et al. (2005) The yeast mitochondrial citrate transport protein: characterization of transmembrane domain III residue involvement in substrate translocation. J Biol Chem 280:2331-40
Cascio, Michael; Mayor, June A; Kaplan, Ronald S (2004) Analysis of the secondary structure of the cys-less yeast mitochondrial citrate transport protein and four single-cys variants by circular dichroism. J Bioenerg Biomembr 36:429-38
Ma, Chunlong; Kotaria, Rusudan; Mayor, June A et al. (2004) The mitochondrial citrate transport protein: probing the secondary structure of transmembrane domain III, identification of residues that likely comprise a portion of the citrate transport pathway, and development of a model for the putative TMDIII-TMDIII J Biol Chem 279:1533-40

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