Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM055002-05
Application #
6431207
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Program Officer
Chin, Jean
Project Start
1997-09-30
Project End
2005-11-30
Budget Start
2001-12-26
Budget End
2002-11-30
Support Year
5
Fiscal Year
2002
Total Cost
$229,993
Indirect Cost
Name
University of Massachusetts Amherst
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
153223151
City
Amherst
State
MA
Country
United States
Zip Code
01003
Samanta, Satamita; Martin, Craig T (2013) Insights into the mechanism of initial transcription in Escherichia coli RNA polymerase. J Biol Chem 288:31993-2003
Ramírez-Tapia, Luis E; Martin, Craig T (2012) New insights into the mechanism of initial transcription: the T7 RNA polymerase mutant P266L transitions to elongation at longer RNA lengths than wild type. J Biol Chem 287:37352-61
Vahia, Ankit V; Martin, Craig T (2011) Direct tests of the energetic basis of abortive cycling in transcription. Biochemistry 50:7015-22
Liu, Xiaoqing; Martin, Craig T (2009) Transcription elongation complex stability: the topological lock. J Biol Chem 284:36262-70
Turingan, Rosemary S; Theis, Karsten; Martin, Craig T (2007) Twisted or shifted? Fluorescence measurements of late intermediates in transcription initiation by T7 RNA polymerase. Biochemistry 46:6165-8
Turingan, Rosemary S; Liu, Cuihua; Hawkins, Mary E et al. (2007) Structural confirmation of a bent and open model for the initiation complex of T7 RNA polymerase. Biochemistry 46:1714-23
Zhou, Yi; Navaroli, Deanna M; Enuameh, Metewo Selase et al. (2007) Dissociation of halted T7 RNA polymerase elongation complexes proceeds via a forward-translocation mechanism. Proc Natl Acad Sci U S A 104:10352-7
Zhou, Yi; Martin, Craig T (2006) Observed instability of T7 RNA polymerase elongation complexes can be dominated by collision-induced ""bumping"". J Biol Chem 281:24441-8
Han, Gang; You, Chang-Cheng; Kim, Byoung-Jin et al. (2006) Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl 45:3165-9
Han, Gang; Martin, Craig T; Rotello, Vincent M (2006) Stability of gold nanoparticle-bound DNA toward biological, physical, and chemical agents. Chem Biol Drug Des 67:78-82

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