Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM055692-03
Application #
2910314
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1997-05-01
Project End
2001-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Pharmacology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Dou, Zhixun; Pan, Ji-An; Dbouk, Hashem A et al. (2013) Class IA PI3K p110? subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Mol Cell 50:29-42
Salamon, Rachel Schnur; Backer, Jonathan M (2013) Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases. Bioessays 35:602-11
Dbouk, Hashem A; Khalil, Bassem D; Wu, Haiyan et al. (2013) Characterization of a tumor-associated activating mutation of the p110* PI 3-kinase. PLoS One 8:e63833
Dbouk, Hashem A; Backer, Jonathan M (2013) Novel approaches to inhibitor design for the p110? phosphoinositide 3-kinase. Trends Pharmacol Sci 34:149-53
Vadas, Oscar; Dbouk, Hashem A; Shymanets, Aliaksei et al. (2013) Molecular determinants of PI3K?-mediated activation downstream of G-protein-coupled receptors (GPCRs). Proc Natl Acad Sci U S A 110:18862-7
Dbouk, Hashem A; Vadas, Oscar; Shymanets, Aliaksei et al. (2012) G protein-coupled receptor-mediated activation of p110? by G?? is required for cellular transformation and invasiveness. Sci Signal 5:ra89
Smirnova, T; Zhou, Z N; Flinn, R J et al. (2012) Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene 31:706-15
Yoon, Mee-Sup; Du, Guangwei; Backer, Jonathan M et al. (2011) Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol 195:435-47
Dbouk, Hashem A; Pang, Huan; Fiser, Andras et al. (2010) A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 107:19897-902
Ciraolo, Elisa; Morello, Fulvio; Hobbs, Robin M et al. (2010) Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. Mol Biol Cell 21:704-11

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