Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM057769-07
Application #
6687306
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Deatherage, James F
Project Start
1997-09-30
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
7
Fiscal Year
2004
Total Cost
$308,629
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Genetics
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Winters, Matthew J; Pryciak, Peter M (2018) Analysis of the thresholds for transcriptional activation by the yeast MAP kinases Fus3 and Kss1. Mol Biol Cell 29:669-682
Repetto, MarĂ­a Victoria; Winters, Matthew J; Bush, Alan et al. (2018) CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5. Mol Cell 69:938-952.e6
Bhaduri, Samyabrata; Valk, Ervin; Winters, Matthew J et al. (2015) A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry. Curr Biol 25:316-325
Pope, Patricia A; Bhaduri, Samyabrata; Pryciak, Peter M (2014) Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1. Curr Biol 24:1390-1396
Pope, Patricia A; Pryciak, Peter M (2013) Functional overlap among distinct G1/S inhibitory pathways allows robust G1 arrest by yeast mating pheromones. Mol Biol Cell 24:3675-88
Bhaduri, Samyabrata; Pryciak, Peter M (2011) Cyclin-specific docking motifs promote phosphorylation of yeast signaling proteins by G1/S Cdk complexes. Curr Biol 21:1615-23
Pryciak, Peter M (2009) Designing new cellular signaling pathways. Chem Biol 16:249-54
Takahashi, Satoe; Pryciak, Peter M (2008) Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade. Curr Biol 18:1184-91
Strickfaden, Shelly C; Pryciak, Peter M (2008) Distinct roles for two Galpha-Gbeta interfaces in cell polarity control by a yeast heterotrimeric G protein. Mol Biol Cell 19:181-97
Strickfaden, Shelly C; Winters, Matthew J; Ben-Ari, Giora et al. (2007) A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway. Cell 128:519-31

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