Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM058160-05A1S1
Application #
6697011
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Schwab, John M
Project Start
1998-07-01
Project End
2006-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
5
Fiscal Year
2003
Total Cost
$49,987
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Dennis, Joseph M; White, Nicholas A; Liu, Richard Y et al. (2018) Breaking the Base Barrier: An Electron-Deficient Palladium Catalyst Enables the Use of a Common Soluble Base in C-N Coupling. J Am Chem Soc 140:4721-4725
Tsai, Erica Y; Liu, Richard Y; Yang, Yang et al. (2018) A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes. J Am Chem Soc 140:2007-2011
Liu, Richard Y; Buchwald, Stephen L (2018) Copper-Catalyzed Enantioselective Hydroamination of Alkenes. Organic Synth 95:80-96
Zhang, Hong; Ruiz-Castillo, Paula; Buchwald, Stephen L (2018) Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols. Org Lett 20:1580-1583
Liu, Richard Y; Bae, Minwoo; Buchwald, Stephen L (2018) Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes. J Am Chem Soc 140:1627-1631
Zhou, Yujing; Bandar, Jeffrey S; Liu, Richard Y et al. (2018) CuH-Catalyzed Asymmetric Reduction of ?,?-Unsaturated Carboxylic Acids to ?-Chiral Aldehydes. J Am Chem Soc 140:606-609
Ichikawa, Saki; Zhu, Shaolin; Buchwald, Stephen L (2018) A Modified System for the Synthesis of Enantioenriched N-Arylamines through Copper-Catalyzed Hydroamination. Angew Chem Int Ed Engl 57:8714-8718
Gribble Jr, Michael W; Guo, Sheng; Buchwald, Stephen L (2018) Asymmetric Cu-Catalyzed 1,4-Dearomatization of Pyridines and Pyridazines without Preactivation of the Heterocycle or Nucleophile. J Am Chem Soc 140:5057-5060
Zhou, Yujing; Engl, Oliver D; Bandar, Jeffrey S et al. (2018) CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes. Angew Chem Int Ed Engl 57:6672-6675
Zhou, Yujing; Bandar, Jeffrey S; Buchwald, Stephen L (2017) Enantioselective CuH-Catalyzed Hydroacylation Employing Unsaturated Carboxylic Acids as Aldehyde Surrogates. J Am Chem Soc 139:8126-8129

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