Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM059167-01
Application #
2826033
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1999-06-01
Project End
2003-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Yale University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Schrage, Ramona; Schmitz, Anna-Lena; Gaffal, Evelyn et al. (2015) The experimental power of FR900359 to study Gq-regulated biological processes. Nat Commun 6:10156
Isom, Daniel G; Dohlman, Henrik G (2015) Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation. Proc Natl Acad Sci U S A 112:5702-7
Clement, Sarah T; Dixit, Gauri; Dohlman, Henrik G (2013) Regulation of yeast G protein signaling by the kinases that activate the AMPK homolog Snf1. Sci Signal 6:ra78
Hurst, Jillian H; Dohlman, Henrik G (2013) Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity. J Biol Chem 288:18660-71
Isom, Daniel G; Sridharan, Vishwajith; Baker, Rachael et al. (2013) Protons as second messenger regulators of G protein signaling. Mol Cell 51:531-8
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Nagiec, Michal J; Dohlman, Henrik G (2012) Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress. PLoS Genet 8:e1002437
Cappell, Steven D; Dohlman, Henrik G (2011) Selective regulation of MAP kinase signaling by an endomembrane phosphatidylinositol 4-kinase. J Biol Chem 286:14852-60
Zhu, Ming; Torres, Matthew P; Kelley, Joshua B et al. (2011) Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast. J Biol Chem 286:27147-55
Torres, Matthew P; Clement, Sarah T; Cappell, Steven D et al. (2011) Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit. J Biol Chem 286:20208-16

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