Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM060651-02
Application #
6351347
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Ikeda, Richard A
Project Start
2000-02-01
Project End
2004-01-31
Budget Start
2001-02-01
Budget End
2002-01-31
Support Year
2
Fiscal Year
2001
Total Cost
$232,607
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Tomasek, James J; Haaksma, Carol J; Schwartz, Robert J et al. (2013) Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen 21:166-76
Howard, Eric W; Crider, Beverly J; Updike, Dawn L et al. (2012) MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype. Exp Cell Res 318:1542-53
Haaksma, Carol J; Schwartz, Robert J; Tomasek, James J (2011) Myoepithelial cell contraction and milk ejection are impaired in mammary glands of mice lacking smooth muscle alpha-actin. Biol Reprod 85:13-21
Crider, Beverly J; Risinger Jr, George M; Haaksma, Carol J et al. (2011) Myocardin-related transcription factors A and B are key regulators of TGF-?1-induced fibroblast to myofibroblast differentiation. J Invest Dermatol 131:2378-85
Mirastschijski, Ursula; Schnabel, Reinhild; Claes, Juliane et al. (2010) Matrix metalloproteinase inhibition delays wound healing and blocks the latent transforming growth factor-beta1-promoted myofibroblast formation and function. Wound Repair Regen 18:223-34
Risinger Jr, George M; Updike, Dawn L; Bullen, Elizabeth C et al. (2010) TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. Am J Physiol Cell Physiol 298:C191-201
Gallucci, Randle M; Lee, Eric G; Tomasek, James J (2006) IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J Invest Dermatol 126:561-8
Tomasek, James J; Vaughan, Melville B; Kropp, Bradley P et al. (2006) Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity. Wound Repair Regen 14:313-20
Mirastschijski, Ursula; Haaksma, Carol J; Tomasek, James J et al. (2004) Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds. Exp Cell Res 299:465-75