Palladium- and nickel-catalyzed cross-coupling reactions serve as extremely powerful tools in organic chemistry, and they been applied to the total synthesis of a wide array of biologically active targets, including apoptolidin, discodermolide, gambierol, palytoxin, ristocetin aglycone, and taxol. During the upcoming grant period, this program will explore a new dimension of cross-coupling reactions-processes that involve alkyl electrophiles as substrates. Efforts will focus on the development of versatile catalysts, including chiral catalysts, for carbon-carbon bond-forming transformations such as the Suzuki, Negishi, Hiyama, Stille, and Sonogashira reactions. Mechanistic studies will play an important role in this project, since an improved understanding of metal-based reactivity should greatly facilitate catalyst development.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM062871-08S1
Application #
7938498
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Schwab, John M
Project Start
2009-09-30
Project End
2009-12-31
Budget Start
2009-09-30
Budget End
2009-12-31
Support Year
8
Fiscal Year
2009
Total Cost
$111,686
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
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Liang, Yufan; Fu, Gregory C (2015) Nickel-Catalyzed Alkyl-Alkyl Cross-Couplings of Fluorinated Secondary Electrophiles: A General Approach to the Synthesis of Compounds having a Perfluoroalkyl Substituent. Angew Chem Int Ed Engl 54:9047-51

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