Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM062920-06
Application #
6526013
Study Section
Special Emphasis Panel (ZRG1-AARR-1 (05))
Program Officer
Ikeda, Richard A
Project Start
1997-07-01
Project End
2004-08-31
Budget Start
2002-09-01
Budget End
2004-08-31
Support Year
6
Fiscal Year
2002
Total Cost
$288,618
Indirect Cost

  Institution

Name
Georgia State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
837322494
City
Atlanta
State
GA
Country
United States
Zip Code
30302

  Publications

Pawar, Shrikant D; Freas, Christopher; Weber, Irene T et al. (2018) Analysis of drug resistance in HIV protease. BMC Bioinformatics 19:362
Wong-Sam, Andres; Wang, Yuan-Fang; Zhang, Ying et al. (2018) Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease. ACS Omega 3:12132-12140
Ghosh, Arun K; R Nyalapatla, Prasanth; Kovela, Satish et al. (2018) Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis. J Med Chem 61:4561-4577
Ghosh, Arun K; Jadhav, Ravindra D; Simpson, Hannah et al. (2018) Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands. Eur J Med Chem 160:171-182
Ghosh, Arun K; Sean Fyvie, W; Brindisi, Margherita et al. (2017) Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands. Bioorg Med Chem Lett 27:4925-4931
Ghosh, Arun K; Fyvie, W Sean; Brindisi, Margherita et al. (2017) Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir. ChemMedChem 12:1942-1952
Gerlits, Oksana; Keen, David A; Blakeley, Matthew P et al. (2017) Room Temperature Neutron Crystallography of Drug Resistant HIV-1 Protease Uncovers Limitations of X-ray Structural Analysis at 100 K. J Med Chem 60:2018-2025
Ghosh, Arun K; Rao, Kalapala Venkateswara; Nyalapatla, Prasanth R et al. (2017) Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants. J Med Chem 60:4267-4278
Ghosh, Arun K; Brindisi, Margherita; Nyalapatla, Prasanth R et al. (2017) Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex. Bioorg Med Chem 25:5114-5127
Ghosh, Arun K; Osswald, Heather L; Glauninger, Kristof et al. (2016) Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation. J Med Chem 59:6826-37

Showing the most recent 10 out of 87 publications