Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM065236-02
Application #
6691716
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Rhoades, Marcus M
Project Start
2003-01-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$310,050
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Biochemistry
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Gainetdinov, Ildar; Colpan, Cansu; Arif, Amena et al. (2018) A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals. Mol Cell 71:775-790.e5
Chou, Min-Te; Han, Bo W; Hsiao, Chiung-Po et al. (2015) Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs. Nucleic Acids Res 43:e109
Han, Bo W; Wang, Wei; Zamore, Phillip D et al. (2015) piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing. Bioinformatics 31:593-5
Wang, Wei; Han, Bo W; Tipping, Cindy et al. (2015) Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms. Mol Cell 59:819-30
Salomon, William E; Jolly, Samson M; Moore, Melissa J et al. (2015) Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides. Cell 162:84-95
Han, Bo W; Wang, Wei; Li, Chengjian et al. (2015) Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production. Science 348:817-21
Fukunaga, Ryuya; Colpan, Cansu; Han, Bo W et al. (2014) Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain. EMBO J 33:371-84
Wang, Wei; Yoshikawa, Mayu; Han, Bo W et al. (2014) The initial uridine of primary piRNAs does not create the tenth adenine that Is the hallmark of secondary piRNAs. Mol Cell 56:708-16
Zhang, Zhao; Koppetsch, Birgit S; Wang, Jie et al. (2014) Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin. EMBO J 33:536-9
Flores-Jasso, C Fabian; Salomon, William E; Zamore, Phillip D (2013) Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates. RNA 19:271-9

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