Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM071725-01S1
Application #
6934350
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Carter, Anthony D
Project Start
2004-08-01
Project End
2009-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
1
Fiscal Year
2004
Total Cost
$6,750
Indirect Cost
Name
Pennsylvania State University
Department
Physiology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Cheng, De; Wang, Shuwen; Jia, Wenwen et al. (2017) Regulation of human and mouse telomerase genes by genomic contexts and transcription factors during embryonic stem cell differentiation. Sci Rep 7:16444
Cheng, De; Zhao, Yuanjun; Wang, Shuwen et al. (2017) Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes. FASEB J 31:1165-1178
Zhang, Fan; Cheng, De; Wang, Shuwen et al. (2016) Human Specific Regulation of the Telomerase Reverse Transcriptase Gene. Genes (Basel) 7:
Cheng, De; Zhao, Yuanjun; Wang, Shuwen et al. (2015) Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1/Sp3 Binding to the Promoter and a Permissive Chromatin Environment. J Biol Chem 290:30193-203
Block, Keith I; Gyllenhaal, Charlotte; Lowe, Leroy et al. (2015) Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol 35 Suppl:S276-S304
Yaswen, Paul; MacKenzie, Karen L; Keith, W Nicol et al. (2015) Therapeutic targeting of replicative immortality. Semin Cancer Biol 35 Suppl:S104-S128
Ma, Yanchun; Hao, Sijie; Wang, Shuwen et al. (2015) A Combinatory Strategy for Detection of Live CTCs Using Microfiltration and a New Telomerase-Selective Adenovirus. Mol Cancer Ther 14:835-43
Zhao, Yuanjun; Cheng, De; Wang, Shuwen et al. (2014) Dual roles of c-Myc in the regulation of hTERT gene. Nucleic Acids Res 42:10385-98
Zhao, Yuanjun; Wang, Shuwen; Zhu, Jiyue (2011) A multi-step strategy for BAC recombineering of large DNA fragments. Int J Biochem Mol Biol 2:199-206
Jia, Wenwen; Wang, Shuwen; Horner, James W et al. (2011) A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis. FASEB J 25:979-89

Showing the most recent 10 out of 19 publications