Studying the synthesis of natural products provides rich opportunities for identifying new directions in chemistry and biology. The overarching goal of our research program is to study the chemical synthesis of small molecules of medicinal relevance and to advance chemical technology for the next-generation of drug synthesis. Through this project, we will better understand how nature performs cycloaddition-type dimerization reactions to produce higher order pyrrole-imidazole alkaloids. We will test the biosynthetic hypotheses and develop biomimetic synthetic approaches to these natural products. Inspired by the oxidative metalloenzymes, we will further develop new catalyst systems for C-H and olefin oxidation. We will also study how cyclic dinucleotides mediate innate immune response. Our research will have direct impacts on the discovery and manufacturing of small-molecule drugs.
This research project is directed toward advancing technologies for drug synthesis and providing insights into how biological systems function. We will develop new chemical methods to enable the efficient synthesis of small-molecule drugs. This project will also help improve our understanding of the biosynthetic machineries and immune systems.
|You, Lin; Chen, Chuo (2018) Rapid access to the core skeleton of the [3 + 2]-type dimeric pyrrole-imidazole alkaloids by triplet ketone-mediated C-H functionalization. Tetrahedron 74:769-772|
|Ma, Zhiqiang; Chen, Chuo (2018) Natural products as inspiration for the development of new synthetic methods. J Chin Chem Soc 65:43-59|
|Han, Lei; Xia, Jibao; You, Lin et al. (2017) Ketone-catalyzed photochemical C(sp3)-H chlorination. Tetrahedron 73:3696-3701|
|Ma, Zhiqiang; You, Lin; Chen, Chuo (2017) Stereocontrolled Formation of a [4.4]Heterospiro Ring System with Unexpected Inversion of Configuration at the Spirocenter. J Org Chem 82:731-736|
|Chen, Chuo (2016) The past, present, and future of the Yang reaction. Org Biomol Chem 14:8641-7|
|Ma, Zhiqiang; Wang, Xiao; Ma, Yuyong et al. (2016) Asymmetric Synthesis of Axinellamines A and B. Angew Chem Int Ed Engl 55:4763-6|
|Zhang, Chengwei; You, Lin; Chen, Chuo (2016) Palladium-Catalyzed C-H Arylation of 1,2,3-Triazoles. Molecules 21:|
|Shi, Heping; De, Saptarshi; Wang, Qiaoling et al. (2015) Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F. Tetrahedron Lett 56:3225-3227|
|Wang, Xiaolei; Chen, Chuo (2015) An approach for the synthesis of nakamuric acid. Tetrahedron 71:3690-3693|
|Ma, Yuyong; De, Saptarshi; Chen, Chuo (2015) Syntheses of Cyclic Guanidine-Containing Natural Products. Tetrahedron 71:1145-1173|
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