Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM098943-10S1
Application #
10140953
Study Section
Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section (NCSD)
Program Officer
Gaillard, Shawn R
Project Start
2012-05-01
Project End
2021-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
10
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Biochemistry
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617

  Publications

Kim, Jin-Kwang; Liu, Jinqiang; Hu, Xichan et al. (2017) Structural Basis for Shelterin Bridge Assembly. Mol Cell 68:698-714.e5
Scott, Harry; Kim, Jin-Kwang; Yu, Clinton et al. (2017) Spatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex. J Mol Biol 429:2863-2872
Wang, Jiyong; Cohen, Allison L; Letian, Anudari et al. (2016) The proper connection between shelterin components is required for telomeric heterochromatin assembly. Genes Dev 30:827-39
Hu, Xichan; Liu, Jinqiang; Jun, Hyun-Ik et al. (2016) Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces. Elife 5:
Liu, Jinqiang; Yu, Clinton; Hu, Xichan et al. (2015) Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis. Cell Rep 12:2169-80
Jun, Hyun-Ik; Liu, Jinqiang; Jeong, Heetae et al. (2013) Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1. Genes Dev 27:1917-31
Tadeo, Xavier; Wang, Jiyong; Kallgren, Scott P et al. (2013) Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly. Genes Dev 27:2489-99