Abstract

The objective of the present proposal is to synthesize and evaluate prostaglandin analogs related to natural PGF2Alpha as potential luteolytic agents. We plan to synthesize in optically pure from 12-hydroxy-16(S)-fluoro PGF2Alpha, 12-hydroxy-16(R)-fluoro PGF2Alpha, 12-hydroxy-14-fluoro PGF2Alpha, 12-hydroxy-16;16-difluoro PGF2Alpha, 12-hydroxy-16-phenoxy-17,18,19,20-tetranor PGF2Alpha, 12-hydroxy-16(3-chlorophenoxy)-17,18,19,20-tetranor PGF2Alpha, and 12-hydroxy-16[3-(trifluoromethyl)phenoxy]-17,18,19,20-tetranor PGF2Alpha.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD014646-06
Application #
3312730
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1980-07-01
Project End
1986-12-31
Budget Start
1985-07-01
Budget End
1986-12-31
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Indiana University Bloomington
Department
Type
Schools of Arts and Sciences
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47402