We have completed a Phase I study of extracorporeal membrane oxygenation (ECMO) in newborn respiratory failure. ECMO was used only in moribund infants (90%+ mortality risk) as determined by the neonatologists and measured by the newborn pulmonary insufficiency index (NPII). Thirty one of 55 infants (56%) survived. The incidence of intracranial bleeding, bronchopulmonary dysplasia, and the expense appears less in the ECMO treated infant. We are currently engaged in a controlled-randomized (Phase II) study of ECMO in newborn respiratory failure. By the end of the current grant year we expect to complete this study in infants over 2 kg birth weight. The results to date indicate that ECMO will be better than conventional ventilator management. We now propose to complete the Phase II study in infants 1-2 kg birth weight, and carry out a Phase III study comparing cost and morbidity in ECMO treated patients to those treated with conventional therapy.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD015434-09
Application #
3313085
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1980-08-01
Project End
1990-03-31
Budget Start
1988-04-01
Budget End
1990-03-31
Support Year
9
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Sun, Liqun; Kaesler, Andreas; Fernando, Piyumindri et al. (2018) CO2 clearance by membrane lungs. Perfusion 33:249-253
Alghanem, Fares; Bryner, Benjamin S; Jahangir, Emilia M et al. (2017) Pediatric Artificial Lung: A Low-Resistance Pumpless Artificial Lung Alleviates an Acute Lamb Model of Increased Right Ventricle Afterload. ASAIO J 63:223-228
Trahanas, John M; Alghanem, Fares; Ceballos-Muriel, Catalina et al. (2017) Development of a Model of Pediatric Lung Failure Pathophysiology. ASAIO J 63:216-222
Fernando, Uditha Piyumindri; Thompson, Alex J; Potkay, Joseph et al. (2017) A Membrane Lung Design Based on Circular Blood Flow Paths. ASAIO J 63:637-643
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Trahanas, John M; Kolobow, Mary Anne; Hardy, Mark A et al. (2016) ""Treating Lungs"": The Scientific Contributions of Dr. Theodor Kolobow. ASAIO J 62:203-10
Wo, Yaqi; Li, Zi; Brisbois, Elizabeth J et al. (2015) Origin of Long-Term Storage Stability and Nitric Oxide Release Behavior of CarboSil Polymer Doped with S-Nitroso-N-acetyl-D-penicillamine. ACS Appl Mater Interfaces 7:22218-27
Brisbois, Elizabeth J; Davis, Ryan P; Jones, Anna M et al. (2015) Reduction in Thrombosis and Bacterial Adhesion with 7 Day Implantation of S-Nitroso-N-acetylpenicillamine (SNAP)-Doped Elast-eon E2As Catheters in Sheep. J Mater Chem B 3:1639-1645
Alghanem, Fares; Davis, Ryan P; Bryner, Benjamin S et al. (2015) The Implantable Pediatric Artificial Lung: Interim Report on the Development of an End-Stage Lung Failure Model. ASAIO J 61:453-8

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