Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD016358-12
Application #
2197300
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1983-09-01
Project End
1998-06-30
Budget Start
1996-09-01
Budget End
1998-06-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Agrawal, Arun K; Shapiro, Bernard H (2005) Neonatal phenobarbital imprints overexpression of cytochromes P450 with associated increase in tumorigenesis and reduced life span. FASEB J 19:470-2
Sharma, Meena R; Periandythevar, Parameswaran; Shapiro, Bernard H (2003) Spurious observation of splenic cyp2b1 expression. Drug Metab Dispos 31:1074-6
Agrawal, Arun K; Shapiro, Bernard H (2003) Constitutive and inducible hepatic cytochrome P450 isoforms in senescent male and female rats and response to low-dose phenobarbital. Drug Metab Dispos 31:612-9
Agrawal, Arun K; Shapiro, Bernard H (2003) Phenobarbital-imprinted overinduction of adult constituent CYP isoforms. Pharmacology 68:204-15
Dhir, Ravindra N; Dworakowski, Wojciech; Shapiro, Bernard H (2002) Middle-age alterations in the sexually dimorphic plasma growth hormone profiles: involvement of growth hormone-releasing factor and effects on cytochrome p450 expression. Drug Metab Dispos 30:141-7
Kaufhold, Antje; Nigam, Prabhat K; Dhir, Ravindra N et al. (2002) Prevention of latently expressed CYP2C11, CYP3A2, and growth hormone defects in neonatally monosodium glutamate-treated male rats by the N-methyl-D-aspartate receptor antagonist dizocilpine maleate. J Pharmacol Exp Ther 302:490-6
Agrawal, A K; Shapiro, B H (2001) Intrinsic signals in the sexually dimorphic circulating growth hormone profiles of the rat. Mol Cell Endocrinol 173:167-81
Garcia, M C; Thangavel, C; Shapiro, B H (2001) Epidermal growth factor regulation of female-dependent CYP2A1 and CYP2C12 in primary rat hepatocyte culture. Drug Metab Dispos 29:111-20
Pampori, N A; Agrawal, A K; Shapiro, B H (2001) Infusion of gender-dependent plasma growth hormone profiles into intact rats: effects of subcutaneous, intraperitoneal, and intravenous routes of rat and human growth hormone on endogenous circulating growth hormone profiles and expression of sexually dim Drug Metab Dispos 29:8-16
Agrawal, A K; Shapiro, B H (2000) Latent overexpression of hepatic CYP2C7 in adult male and female rats neonatally exposed to phenobarbital: a developmental profile of gender-dependent P450s. J Pharmacol Exp Ther 293:1027-33

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