This proposal describes studies of the development of behavioral and hormonal responses to stressors during infancy and early childhood. In addition to a longitudinal study (prenatal period to age 3), a large study of children responding to the challenges of preschool, and several smaller studies are also proposed. This research is organized around examination of the hypothalamic-pituitary-adrenocortical (HPA) system, a neuroendocrine system central to mammalian stress resistance. A major goal of this work is to integrate studies of the psychobiology of this system with research on the biological substrate of temperament in children. To this end, the studies described examine components of a proposed temperament-coping resources-physiological stress model. According to this model, the biological substrate of temperament (assessed through measures of baseline EEG asymmetry, vagal tone, basal HPA activity, and positive late components of the ERP) influences the child's likelihood of perceiving events as potentially threatening. However, activation of physiological stress reactions are presumed to follow from expectations that the threat will be realized. Mediating these perceptions are the coping resources available to the child. The studies will take advantage of both lab-based and naturalistic-ecological stressors and challenging situations. The proposed studies are designed to integrate 3 major literatures: (1) the physiology of infant/child temperament, (2) socioemotional development, including attachment research, and (3) psychoendocrine studies of infant/child stress. Finally, preliminary investigations of a noninvasive measure of immune functioning (salivary interleukin-1b) are also proposed that would extend this integration to research on individual differences in children's physical health and susceptibility to illness.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD016494-17
Application #
2673464
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Program Officer
Freund, Lisa S
Project Start
1982-04-01
Project End
1999-09-30
Budget Start
1998-04-01
Budget End
1999-09-30
Support Year
17
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Pediatrics
Type
Schools of Education
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Kertes, Darlene A; Donzella, Bonny; Talge, Nicole M et al. (2009) Inhibited temperament and parent emotional availability differentially predict young children's cortisol responses to novel social and nonsocial events. Dev Psychobiol 51:521-32
Van Ryzin, Mark J; Chatham, Melissa; Kryzer, Erin et al. (2009) Identifying atypical cortisol patterns in young children: The benefits of group-based trajectory modeling. Psychoneuroendocrinology 34:50-61
Talge, Nicole M; Donzella, Bonny; Gunnar, Megan R (2008) Fearful Temperament and Stress Reactivity Among Preschool-Aged Children. Infant Child Dev 17:427-445
Gunnar, Megan R; Donzella, Bonny (2004) Tympanic membrane temperature and emotional dispositions in preschool-aged children: a methodological study. Child Dev 75:497-504
Gunnar, Megan R; Sebanc, Anne M; Tout, Kathryn et al. (2003) Peer rejection, temperament, and cortisol activity in preschoolers. Dev Psychobiol 43:346-58
Watamura, Sarah E; Donzella, Bonny; Alwin, Jan et al. (2003) Morning-to-afternoon increases in cortisol concentrations for infants and toddlers at child care: age differences and behavioral correlates. Child Dev 74:1006-20
Watamura, Sarah E; Sebanc, Anne M; Gunnar, Megan R (2002) Rising cortisol at childcare: relations with nap, rest, and temperament. Dev Psychobiol 40:33-42
Dettling, A C; Parker, S W; Lane, S et al. (2000) Quality of care and temperament determine changes in cortisol concentrations over the day for young children in childcare. Psychoneuroendocrinology 25:819-36
Donzella, B; Gunnar, M R; Krueger, W K et al. (2000) Cortisol and vagal tone responses to competitive challenge in preschoolers: associations with temperament. Dev Psychobiol 37:209-20
White, B P; Gunnar, M R; Larson, M C et al. (2000) Behavioral and physiological responsivity, sleep, and patterns of daily cortisol production in infants with and without colic. Child Dev 71:862-77

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