The objective of this application is to understand the molecular mechanisms involved in the hormonal regulation and tissue-specific expression of the GnRHR gene.
The specific aims i nclude 1) determine the physiologic regulation of GnRHR gene transcription and mRNA stability in vivo and in vitro by GnRH, activin, and estrogen; 2) identify and characterize functional cis-DNA elements of the mouse GnRHR gene and identify factors which interact with these elements; 3) identify and characterize cis-DNA elements and factors that mediate GnRH responsiveness; 4) use the 5'-flanking region of the GnRHR gene to direct oncogene expression to the pituitary in an attempt to develop LH- and FSH-producing cell lines; and 5) use GnRHR transgenes to study the regulation by GnRH, activin, and steroid hormones.
|Stamatiades, George A; Kaiser, Ursula B (2018) Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression. Mol Cell Endocrinol 463:131-141|
|Ross, Rachel A; Leon, Silvia; Madara, Joseph C et al. (2018) PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife 7:|
|Zheng, Junjie; Mao, Jiangfeng; Xu, Hongli et al. (2017) Pulsatile GnRH Therapy May Restore Hypothalamus-Pituitary-Testis Axis Function in Patients With Congenital Combined Pituitary Hormone Deficiency: A Prospective, Self-Controlled Trial. J Clin Endocrinol Metab 102:2291-2300|
|Ercan, Altan; Kohrt, Wendy M; Cui, Jing et al. (2017) Estrogens regulate glycosylation of IgG in women and men. JCI Insight 2:e89703|
|Bi, Wenya Linda; Greenwald, Noah F; Ramkissoon, Shakti H et al. (2017) Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors. Endocrinology 158:2284-2291|
|Mao, Jiang-Feng; Liu, Zhao-Xiang; Nie, Min et al. (2017) Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism. Asian J Androl 19:680-685|
|Maguire, Caroline A; Song, Yong Bhum; Wu, Min et al. (2017) Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse. Endocrinology 158:2319-2329|
|Lee, Hyunju; Hodi, F Stephen; Giobbie-Hurder, Anita et al. (2017) Characterization of Thyroid Disorders in Patients Receiving Immune Checkpoint Inhibition Therapy. Cancer Immunol Res 5:1133-1140|
|Abreu, Ana Paula; Kaiser, Ursula B (2016) Pubertal development and regulation. Lancet Diabetes Endocrinol 4:254-264|
|Simavli, Serap; Abreu, Ana Paula; Kwaan, Mary R et al. (2016) Candidate gene analysis in a case of congenital absence of the endometrium. Fertil Res Pract 2:3|
Showing the most recent 10 out of 86 publications