The long range goal of this proposal is to examine the interaction between regular exercise and the course and outcome of the pregnancy.
Its specific aims are: to determine if regular exercise induces changes in maternal physiological function and placental growth and functional capacity and thereby improve fetal growth and pregnancy outcome in a variety of populaces, to assess the modulatory role of diet on these exercise effects, and to determine if the beneficial effects of exercise are regulated in part by decreasing the need for flow redistribution during cardiovascular stress. It will test 3 hypotheses. First, that beginning a program of regular exercise early in the second trimester will reduce the incidence of preterm birth and low birth weight in demographically at risk populaces. Second, that dietary carbohydrate mix modifies the impact of exercise on maternal weight gain, fat deposition, feto-placental growth and size at birth. Third, different threshold volumes of regular exercise are required to produce each specific beneficial effect. It is based on earlier studies which indicate that regular exercise during pregnancy has positive effects for both mother and fetus in two specific populaces of women. It will complete prospective, randomized training studies in two groups of women who are at low demographic risk and in two groups of women who are at high demographic risk for poor outcome. The techniques employed include: respiratory calorimetry and doubly labeled water for energy expenditure, ultrasound for measuring feto-placental growth, total body electrical conductivity and 18/O for body composition, along with other gross and histomorphometric techniques. The proposal should determine the preventive value of regular exercise in both low and high risk pregnancy and provide insight into several mechanisms which regulate its beneficial effects.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD021268-13
Application #
6125633
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Spong, Catherine
Project Start
1986-04-01
Project End
2001-03-31
Budget Start
1999-12-01
Budget End
2001-03-31
Support Year
13
Fiscal Year
2000
Total Cost
$242,932
Indirect Cost
Name
Case Western Reserve University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Clapp 3rd, James F (2008) Long-term outcome after exercising throughout pregnancy: fitness and cardiovascular risk. Am J Obstet Gynecol 199:489.e1-6
Clapp, J F (2006) Influence of endurance exercise and diet on human placental development and fetal growth. Placenta 27:527-34
Jeffreys, R M; Stepanchak, W; Lopez, B et al. (2006) Uterine blood flow during supine rest and exercise after 28 weeks of gestation. BJOG 113:1239-47
Clapp 3rd, James F; Schmidt, Stephanie; Paranjape, Aditi et al. (2004) Maternal insulin-like growth factor-I levels (IGF-I) reflect placental mass and neonatal fat mass. Am J Obstet Gynecol 190:730-6
Bergmann, A; Zygmunt, M; Clapp 3rd, J F (2004) Running throughout pregnancy: effect on placental villous vascular volume and cell proliferation. Placenta 25:694-8
Clapp 3rd, James F (2003) The effects of maternal exercise on fetal oxygenation and feto-placental growth. Eur J Obstet Gynecol Reprod Biol 110 Suppl 1:S80-5
Clapp 3rd, James F; Little, Kathleen D; Widness, John A (2003) Effect of maternal exercise and fetoplacental growth rate on serum erythropoietin concentrations. Am J Obstet Gynecol 188:1021-5
Clapp 3rd, James F; Kim, Hyungjin; Burciu, Brindusa et al. (2002) Continuing regular exercise during pregnancy: effect of exercise volume on fetoplacental growth. Am J Obstet Gynecol 186:142-7
Clapp 3rd, James F (2002) Maternal carbohydrate intake and pregnancy outcome. Proc Nutr Soc 61:45-50
Clapp 3rd, J F; Kim, H; Burciu, B et al. (2000) Beginning regular exercise in early pregnancy: effect on fetoplacental growth. Am J Obstet Gynecol 183:1484-8

Showing the most recent 10 out of 41 publications