The overall goal of the research is to understand the developmental processes that take place in Chip embryonic limb. In this developmental system, changes occur in the activity of a number of genes at the time of differentiation of limb mesodermal cells into chondrocytes. We will study: a) the structure-function relationship of the translation products of newly activated genes in the establishment of the cartilaginous matrix, b) the regulatory sequences that are specific for the expression of one of these genes in chondrocytes and c) the morphogenetic consequences of induced and spontaneous mutations that affect cartilage matrix macromolecules.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD022016-07
Application #
3321241
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1986-01-01
Project End
1991-10-31
Budget Start
1991-03-01
Budget End
1991-10-31
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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