Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
7R01HD022590-10
Application #
2403153
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1986-12-01
Project End
2000-04-30
Budget Start
1996-12-01
Budget End
1997-04-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Emory University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Hathaway, Helen J; Evans, Susan C; Dubois, Daniel H et al. (2003) Mutational analysis of the cytoplasmic domain of beta1,4-galactosyltransferase I: influence of phosphorylation on cell surface expression. J Cell Sci 116:4319-30
Shi, X; Amindari, S; Paruchuru, K et al. (2001) Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling. Development 128:645-54
Wassler, M J; Shur, B D (2000) Clustering of cell surface (beta)1,4-galactosyltransferase I induces transient tyrosine phosphorylation of focal adhesion kinase and loss of stress fibers. J Cell Sci 113 Pt 2:237-45
Johnson, F M; Shur, B D (1999) The level of cell surface beta1,4-galactosyltransferase I influences the invasive potential of murine melanoma cells. J Cell Sci 112 ( Pt 16):2785-95
Lu, Q; Shur, B D (1997) Sperm from beta 1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly. Development 124:4121-31
Lu, Q; Hasty, P; Shur, B D (1997) Targeted mutation in beta1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality. Dev Biol 181:257-67
Hinton, D A; Evans, S C; Shur, B D (1995) Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth. Exp Cell Res 219:640-9
Gong, X; Dubois, D H; Miller, D J et al. (1995) Activation of a G protein complex by aggregation of beta-1,4-galactosyltransferase on the surface of sperm. Science 269:1718-21
Youakim, A; Shur, B D (1994) Alteration of oligosaccharide biosynthesis by genetic manipulation of glycosyltransferases. Ann N Y Acad Sci 745:331-5
Youakim, A; Hathaway, H J; Miller, D J et al. (1994) Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions. J Cell Biol 126:1573-83

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