Abstract

A new psychophysiological measurement strategy will be assessed in human neonates. The proposed research will focus on evaluating the relationship between central nervous system (CNS) dysfunction, causal in many forms of behavior disorders, and autonomic nervous system (ANS) activity. The research will evalate the hypothesis that rhythmic heart rate patterns, specifically respiratory-sinus arrhythmia, reflect neural influences and will be sensitive to cortical pathologies. The specific objective of the proposed research is to identify CNS dysfunction in neonates through non-invasive monitoring of heart rate and respiration. In preliminary research spectral analysis techniques have been developed which have been successful in identifying and quantifying a component of heart rate variability which covaries with vagal tone (V). In a pilot study with neonates, V was related to general CNS status. The proposed research is an attempt to evaluate the sensitivity of V as an assessment index of known pathophysiological states in brain-damaged infants and to related measures of V at birth to duration of hospitalization and outcome. The techniques tested in the proposed research may evolve into an assessment technique sensitive to subtle individual differences in CNS functioning and predictive of future behavior.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD022628-04
Application #
3322398
Study Section
Human Development and Aging Subcommittee 1 (HUD)
Project Start
1987-07-01
Project End
1989-06-30
Budget Start
1988-05-01
Budget End
1989-06-30
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Maryland College Park
Department
Type
Schools of Education
DUNS #
City
College Park
State
MD
Country
United States
Zip Code
20742

  Publications

Dale, Lourdes P; O'Hara, Emily A; Keen, Julie et al. (2011) Infant regulatory disorders: temperamental, physiological, and behavioral features. J Dev Behav Pediatr 32:216-24
Bazhenova, Olga V; Stroganova, Tatiana A; Doussard-Roosevelt, Jane A et al. (2007) Physiological responses of 5-month-old infants to smiling and blank faces. Int J Psychophysiol 63:64-76
Doussard-Roosevelt, Jane A; Joe, Claudia M; Bazhenova, Olga V et al. (2003) Mother-child interaction in autistic and nonautistic children: characteristics of maternal approach behaviors and child social responses. Dev Psychopathol 15:277-95
Porges, S W (2001) The polyvagal theory: phylogenetic substrates of a social nervous system. Int J Psychophysiol 42:123-46
Doussard-Roosevelt, J A; McClenny, B D; Porges, S W (2001) Neonatal cardiac vagal tone and school-age developmental outcome in very low birth weight infants. Dev Psychobiol 38:56-66
Bazhenova, O V; Plonskaia, O; Porges, S W (2001) Vagal reactivity and affective adjustment in infants during interaction challenges. Child Dev 72:1314-26
Suess, P E; Alpan, G; Dulkerian, S J et al. (2000) Respiratory sinus arrhythmia during feeding: a measure of vagal regulation of metabolism, ingestion, and digestion in preterm infants. Dev Med Child Neurol 42:169-73
DiPietro, J A; Costigan, K A; Pressman, E K et al. (2000) Antenatal origins of individual differences in heart rate. Dev Psychobiol 37:221-8
Porges, S W; Doussard-Roosevelt, J A; Stifter, C A et al. (1999) Sleep state and vagal regulation of heart period patterns in the human newborn: an extension of the polyvagal theory. Psychophysiology 36:14-21
Reed, S F; Ohel, G; David, R et al. (1999) A neural explanation of fetal heart rate patterns: A test of the polyvagal theory. Dev Psychobiol 35:108-18

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