Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD023089-10A2
Application #
2198761
Study Section
Immunobiology Study Section (IMB)
Project Start
1990-04-01
Project End
2001-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Genetics
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Shen, X; Bozek, G; Pinkert, C A et al. (1999) The C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation. Int Immunol 11:1663-71
Kurtz, B S; Witte, P L; Storb, U (1997) Gamma 2b provides only some of the signals normally given via mu in B cell development. Int Immunol 9:415-26
Roth, P E; Kurtz, B; Lo, D et al. (1995) lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line. J Exp Med 181:1059-70
Weng, A; Engler, P; Storb, U (1995) The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status. Mol Cell Biol 15:572-9
Doglio, L; Kim, J Y; Bozek, G et al. (1994) Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage. Dev Immunol 4:13-26
Storb, U; Roth, P; Kurtz, B K (1994) Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development. Immunol Res 13:291-8
Engler, P; Weng, A; Storb, U (1993) Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate. Mol Cell Biol 13:571-7
Storb, U (1993) Steps in the generation of autoantibodies. Ann N Y Acad Sci 681:29-32
Roth, P E; Doglio, L; Manz, J T et al. (1993) Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development. J Exp Med 178:2007-21
Storb, U; Engler, P; Klotz, E et al. (1992) Rearrangement and expression of immunoglobulin genes in transgenic mice. Curr Top Microbiol Immunol 182:137-41

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