Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
7R01HD023696-03
Application #
3323884
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1989-09-01
Project End
1993-01-31
Budget Start
1989-09-01
Budget End
1990-01-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Miduturu, Chandrasekhar V; Deng, Xianming; Kwiatkowski, Nicholas et al. (2011) High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol 18:868-79
Gadea, Bedrick B; Ruderman, Joan V (2006) Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin. Proc Natl Acad Sci U S A 103:4493-8
Liu, Quentin; Ruderman, Joan V (2006) Aurora A, mitotic entry, and spindle bipolarity. Proc Natl Acad Sci U S A 103:5811-6
Selenko, Philipp; Serber, Zach; Gadea, Bedrick et al. (2006) Quantitative NMR analysis of the protein G B1 domain in Xenopus laevis egg extracts and intact oocytes. Proc Natl Acad Sci U S A 103:11904-9
Stanford, Jennifer S; Ruderman, Joan V (2005) Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests. Mol Biol Cell 16:5749-60
Gadea, Bedrick B; Ruderman, Joan V (2005) Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts. Mol Biol Cell 16:1305-18
Crane, Richard; Kloepfer, Angela; Ruderman, Joan V (2004) Requirements for the destruction of human Aurora-A. J Cell Sci 117:5975-83
Tsai, Ming-Ying; Wiese, Christiane; Cao, Kan et al. (2003) A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol 5:242-8
Yam, C H; Siu, W Y; Kaganovich, D et al. (2001) Cleavage of cyclin A at R70/R71 by the bacterial protease OmpT. Proc Natl Acad Sci U S A 98:497-501
Farruggio, D C; Townsley, F M; Ruderman, J V (1999) Cdc20 associates with the kinase aurora2/Aik. Proc Natl Acad Sci U S A 96:7306-11

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